Phys. Rev. E 81, 051918 (2010) [7 pages]Ionization penalty in nonlinear optical bioimagingReceived 20 October 2009; revised 2 February 2010; published 17 May 2010 The noninvasiveness of nonlinear optical imaging techniques is quantified in terms of the number of free electron generated in the laser-tissue interaction region per photon emitted into the nonlinear optical signal. For a broad variety of biomarker dyes and bioactivity reporter proteins, this ratio is shown to approach a critical value of unity for field intensities above 1 TW/cm2. Closed-form analytical expressions for the ionization penalty function and the critical pulse repetition rate are derived for few-cycle laser pulses. © 2010 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevE.81.051918
DOI:
10.1103/PhysRevE.81.051918
PACS:
87.64.-t, 33.80.Rv
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