Mixing-induced aggregation and associated microstructures in the capillary flow

With a device that uses microscopic imaging as the signal detection method for online laser light scattering of solutions driven to flow in a capillary tube, we have found that mixing of a solution with water and vice versa induce large numbers of aggregates in the free flow stream. The degrees of aggregation as measured from the total number of aggregates and the corresponding light-scattering intensities are dependent on the species of the solution. This species dependence of the mixing aggregation in the capillary flow has the potential for the development of new protocols or even spectroscopic methods for the detection of solute molecules and the assessment of solution qualities. Furthermore, even with pure-distilled and de-ionized water in the steady-state capillary flow, there are still countable numbers of aggregates detectable in the free flow stream, although of extremely low concentration of an estimated value of no more than 10⁻¹⁵ M.