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Phys. Rev. E 75, 050901(R) (2007) [4 pages]

Towards neuro-memory-chip: Imprinting multiple memories in cultured neural networks

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Itay Baruchi and Eshel Ben-Jacob
School of Physics and Astronomy, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel

Received 3 August 2006; published 16 May 2007

We show that using local chemical stimulations it is possible to imprint persisting (days) multiple memories (collective modes of neuron firing) in the activity of cultured neural networks. Microdroplets of inhibitory antagonist are injected at a location selected based on real-time analysis of the recorded activity. The neurons at the stimulated locations turn into a focus for initiating synchronized bursting events (the collective modes) each with its own specific spatiotemporal pattern of neuron firing.

© 2007 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevE.75.050901
DOI:
10.1103/PhysRevE.75.050901
PACS:
87.19.La, 84.35.+i