Phys. Rev. E 74, 021915 (2006) [6 pages]Signaling between cells attached to a surfaceReceived 26 May 2006; revised 10 July 2006; published 17 August 2006 We present a kinetic model allowing one to classify likely scenarios of protein-mediated communication between attached cells of two distinct types. In our treatment, messenger proteins, synthesized in type-1 cells, are considered to penetrate the external membrane of these cells, diffuse in the extracellular medium, associate with the receptors in the external membrane of cells of both types, and induce intracellular signal transduction cascades, influencing the development of cells. Protein degradation inside and outside cells is taken into account as well. © 2006 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevE.74.021915
DOI:
10.1103/PhysRevE.74.021915
PACS:
87.16.Xa, 87.17.−d, 87.18.−h
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