Phys. Rev. E 72, 031906 (2005) [6 pages]Modeling DNA unzipping in the presence of bound proteinsReceived 15 September 2004; revised 6 April 2005; published 14 September 2005 Unzipping force analysis of protein association is a technique to investigate protein-DNA interactions by mechanically unzipping DNA. We computationally investigate the limits of this technique under quasistatic conditions. We find the minimum binding energy of a protein for which the protein can be detected using this technique and the minimum distance between the binding sites of two proteins of varying binding energies that can be resolved unambiguously with this technique. © 2005 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevE.72.031906
DOI:
10.1103/PhysRevE.72.031906
PACS:
87.15.Aa
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