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Phys. Rev. E 72, 016216 (2005) [4 pages]

Thresholds of excitability in three-dimensional dynamical systems

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Michal Voslař and Igor Schreiber*
Department of Chemical Engineering and Center for Nonlinear Dynamics of Chemical and Biological Systems, Prague Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic

Received 21 January 2005; published 22 July 2005

A two-dimensional threshold surface of an excitable system is found as a set of threshold trajectories calculated step by step in cross sections of the phase space. The method leads to a highly nonlinear boundary value problem that can be solved numerically with the use of adaptive multiple shooting and continuation methods. We demonstrate this technique by examining a model of a biochemical oscillator with two positive feedbacks. Generalization to arbitrary dimension is discussed.

© 2005 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevE.72.016216
DOI:
10.1103/PhysRevE.72.016216
PACS:
05.45.−a, 82.20.Wt

*Electronic address: Igor.Schreiber@vscht.cz