Phys. Rev. E 70, 060901(R) (2004) [4 pages]

Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels

Abstract

References

Citing Articles (42)

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Y.-L. Chen, M. D. Graham^*, and J. J. de Pablo^†
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53703, USA

G. C. Randall, M. Gupta, and P. S. Doyle^‡
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

Received 20 August 2004; published 13 December 2004

The conformation and diffusion of a single DNA molecule confined between two parallel plates are examined using both single molecule experiments and Brownian dynamics simulations accounting for hydrodynamic interactions. The degree of chain stretching and the diffusivity are characterized as a function of the chain confinement and the channel geometry. Good agreement is found between the simulations, experiments, and scaling theory predictions.

URL:

http://link.aps.org/doi/10.1103/PhysRevE.70.060901

DOI:

10.1103/PhysRevE.70.060901

PACS:

87.15.He, 83.50.Ha, 83.10.Mj

^*Electronic address: graham@engr.wisc.edu

^†Electronic address: depablo@engr.wisc.edu

^‡Electronic address: pdoyle@mit.edu

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Phys. Rev. E 70, 060901(R) (2004) [4 pages]

Conformation and dynamics of single DNA molecules in parallel-plate slit microchannels