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Phys. Rev. E 70, 041908 (2004) [12 pages]

Solvable biological evolution models with general fitness functions and multiple mutations in parallel mutation-selection scheme

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David B. Saakian1,2, Chin-Kun Hu1,*, and H. Khachatryan2
1Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan
2Yerevan Physics Institute, Alikhanian Brothers Street 2, Yerevan 375036, Armenia

Received 8 June 2004; published 28 October 2004

In a recent paper [ Phys. Rev. E 69 046121 (2004)], we used the Suzuki-Trottere formalism to study a quasispecies biological evolution model in a parallel mutation-selection scheme with a single-peak fitness function and a point mutation. In the present paper, we extend such a study to evolution models with more general fitness functions or multiple mutations in the parallel mutation-selection scheme. We give some analytical equations to define the error thresholds for some general cases of mean-field-like or symmetric mutation schemes and fitness functions. We derive some equations for the dynamics in the case of a point mutation and polynomial fitness functions. We derive exact dynamics for two-point mutations, asymmetric mutations, and the four-value spin model with a single-peak fitness function. The same method is applied for the model with a royal road fitness function. We derive the steady-state distribution for the single-peak fitness function.

© 2004 The American Physical Society

URL:
http://link.aps.org/doi/10.1103/PhysRevE.70.041908
DOI:
10.1103/PhysRevE.70.041908
PACS:
87.23.Kg, 87.10.+e, 87.15.Aa, 02.50.−r

*Author to whom correspondence should be addressed. Electronic address: huck@phys.sinica.edu.tw