Phys. Rev. E 70, 041901 (2004) [6 pages]Base-sequence-dependent sliding of proteins on DNAReceived 27 November 2003; revised 19 May 2004; published 6 October 2004 The possibility that the sliding motion of proteins on DNA is influenced by the base sequence through a base pair reading interaction, is considered. Referring to the case of the T7 RNA-polymerase, we show that the protein should follow a noise-influenced sequence-dependent motion which deviate from the standard random walk usually assumed. The general validity and the implications of the results are discussed. © 2004 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevE.70.041901
DOI:
10.1103/PhysRevE.70.041901
PACS:
87.14.Ee, 87.15.Aa, 87.15.Vv
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