Phys. Rev. E 57, 2471–2474 (1998)Selection-mutation process of RNA virusesReceived 1 August 1997; published in the issue dated February 1998 RNA viruses mutate at a rate 105–106 times faster than their DNA counterparts. This process can be simulated by a continuous stochastic model on a smooth one-dimensional fitness landscape where selection forces the viral quasispecies to climb uphill to higher fitness values. Theoretical results of the model with drift velocity proportional to fitness are fitted to the experimental observations made by Novella et al. [Proc. Natl. Acad. Sci. U.S.A. 92, 5841 (1995)]. © 1998 The American Physical Society URL:
http://link.aps.org/doi/10.1103/PhysRevE.57.2471
DOI:
10.1103/PhysRevE.57.2471
PACS:
87.10.+e
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